The NOD2 3020insC Mutation and The Risk of Familial Pancreatic Cancer?
نویسندگان
چکیده
1Inter-University Unit of Molecular Biology, University of Szczecin and Pomeranian Medical University, Szczecin, Poland; 2Department of Surgery, Philipps-University, Marburg, Germany; 3Institute of Clinical Genetics, Philipps-University, Marburg, Germany; 4Department of Internal Medicine, Hospital Langendreer, Ruhr-University, Bochum, Germany; 5International Hereditary Cancer Center, Department of Genetics and Pathology, Szczecin, Poland
منابع مشابه
The 3020insC NOD2 gene mutation in patients with ovarian cancer.
OBJECTIVE There is an increasing evidence that genetic factors play a role in the etiology of malignant tumors. Mutations of BRCA1 and BRCA2 genes are responsible for an increased risk of ovarian cancer. The role of mutations in NOD2 gene in this type of neoplasm is still under investigation. THE AIM The aim of this study was to determine: 1. incidence of NOD 2 3020insC constitutional mutatio...
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Several predispositions to colorectal cancer have been identified, but little is known about genetic susceptibilities to disease in older persons. Colorectal cancer is a risk in Crohn's disease and is believed to be associated with an inappropriate inflammatory response. Recently, the NOD2 gene has been associated with Crohn's disease, which further strengthens the notion that the inflammatory ...
متن کاملThe NOD2 3020insC Mutation in Women with Breast Cancer from the Bydgoszcz Region in Poland. First Results
The frameshift NOD2 gene mutation 3020insC is predominantly associated with Crohn's disease, but predisposes to many types of common cancers as well. We studied the frequency of this mutant NOD2 allele in 148 breast cancer women from the Bydgoszcz region in Poland. The NOD2 mutation was present in 8.8% of the patients. The mean age at breast cancer diagnosis of the mutation carriers was 43 year...
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عنوان ژورنال:
دوره 2 شماره
صفحات -
تاریخ انتشار 2004